Novel IL4/IL4RA double humanized mouse models for in vivo efficacy evaluation of human IL4 and human IL4RA antibodies in asthma models

Pleiotropic cytokines (interleukin(IL)-4/13) and their pertinent receptors (such as IL-4 receptor) are promising therapeutic targets due to their pivotal roles in the physiopathology of asthma, atopic dermatitis (AD), and other auto-immune diseases.

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RenMab? Mouse: a leading platform for fully human antibody generation

herapeutic antibodies have been proven to be remarkably effective for immunotherapies.

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Efficacy and toxicity evaluation of anti-human CD47 and SIRPa antibodies in genetically humanized B-hSIRPa/hCD47 mice

CD47 is a transmembrane protein expressed ubiquitously on the surface of human cells, including. SIRPa, one of the binding partners of CD47, is a member of the signal-regulatory-protein (SIRP) family which is expressed on many myeloid cells including phag

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Novel humanized CD3ε mouse model for evaluation of bi-specific T-cell engager antibodies

CD3ε is one of the key signaling subunits of the CD3 co-receptor of the T cell receptor (TCR) complex. This TCR complex plays critical role in mediating T cell activation and cellular immune response.

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Rapid Therapeutic Antibody Development Using Fully Human Antibody Mouse

Therapeutic antibodies have been proven to be remarkably effective for immunotherapies. Most human antibodies were discovered through conventional antibody discovery process,

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The Human Immune System Reconstituted B-NDG Mouse Models are Perfect Tools for CAR-T and Therapeutic Antibody Preclinical Efficacy Evaluation

The B-NDG mice (NOD-Prkdcscid Il2rgtm1/Bcgen) were independently developed by Biocytogen to knockout IL2rg gene in NOD-SCID mouse background. Here we demonstrated that B-NDG, as one of the most severe immunodeficient mice, completely lack of mature T, B,

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Anti-SIRPα Antibodies as A Potential Weapon for Cancer Immunotherapy via Accelerated Screening in Humanized Mouse Models

Signal regulatory protein α (SIRPα) is a transmembrane protein and is especially abundant in myeloid cells such as macrophages and DCs, whereas it is expressed at very low levels in T, B and NK cells.

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Novel hCD3e Mouse Models for Preclinical Pharmacology Study of Therapeutic Bispecific Antibody

CD3e is one of four subunits of the CD3 co-receptor, which plays an important role in the immune response, associating with the T cell receptor (TCR) to couple antigen recognition to intracellular signal transduction, leading to T cell activation.

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Rapid Screening of Anti-OX40 Antibodies for Cancer Immunotherapy

OX40 is a co-stimulatory receptor, and it interacts with its ligand to provide positive signal for T cell activation. Disruption of the OX40 pathway led to defective T cell responses and overexpression of OX40 caused massive immune activation.

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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development

4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells, dendritic cells, and activated endothelium.

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Evaluating Anti-PD-1/CD40 In Vivo Efficacy and Safety on Humanized Double Knock-in Mice

Over the past years, monoclonal antibodies have been successfully utilized in clinical trials to block or active key mediators of immune checkpoint pathways. However, along the IO drug development process,

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Novel CTLA-4 Antibodies of Potent Antitumor Activity Were Verified in Humanized Mouse Models

CTLA-4 is a member of the immunoglobulin superfamily, and is homologous to the co-stimulatory protein CD28, and both receptors bind to the same ligands, CD80(B7-1) and CD86(B7-2).

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