Nature Research Webcast: Accelerating therapeutic antibody discovery with fully human antibody mice

Nature Research Webcast: Accelerating therapeutic antibody discovery with fully human antibody mice

Date: December 10, 2019
Time: 8am PST / 11am EST / 4pm GMT / 5pm CET



Production of fully human antibody is a critical step in the antibody discovery process. In many cases, hybridoma with genetically modified animals or post-optimization humanization are often employed to generate humanized antibodies.

Amid the laborious procedures, some major challenges are compromised immune response of the animal models and insufficient diversity of the antibody repertoire.

To address these issues, Biocytogen has utilized chromosome engineering to generate mouse models that can rapidly produce fully human antibodies. Biocytogen’s chromosome engineering technology allows the in situ replacement of the entire mouse immunoglobin (Ig) heavy chain region (VDJ) and mouse kappa light chain VJ regions with the full human counterparts.

This mouse model has been shown to have a similar immune response to the wildtype strain as it carries the full human antibody repertoire. In conjunction with the unique in vivo ranking workflow using humanized mice models, Biocytogen has developed a streamlined antibody discovery process that could take a drug candidate to clinical trials several months ahead of schedule.

This webcast will answer:

  • How do fully human antibody mice accelerate therapeutic antibody discovery?

  • What’s the advantage of Bicoytogen’s fully human antibody platform over conventional human antibody production processes?

  • What’s the most efficient way to save your time to take an antibody drug candidate to clinical trials?


Dr. Benny Yang

Chief Scientific Officer & Director of Antibody Discovery, Biocytogen

Dr. Yang received Ph.D. in Immunology from the University of Connecticut Health Center (UCHC) and completed postdoctoral training at NYU School of Medicine in Dr. Dan Littman’s research group. He was recruited to the Medical University of South Carolina (MUSC) as a tenure-track Assistant Professor at the Department of Microbiology and Immunology. Dr. Yang has been leading the antibody drug discovery platform since he joined Biocytogen in 2016.


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